Dr Hannah V Siddle is Lecturer in Molecular Biology within Biological Sciences at the ºÚÁÏÉç.
Career History
2019 - present
: Associate Professor in Molecular Immunology, ºÚÁÏÉç, UK.
2013-2019
: Lecturer in Molecular Biology, ºÚÁÏÉç, UK.
2011-2013
: EMBO Postdoctoral Research Fellow. University of Cambridge, UK.
2009-2011
: NHMRC Postdoctoral Research Fellow. University of Cambridge, UK.
Academic Qualifications
2005-2009:
PhD (Evolutionary genomics and genetics). University of Sydney, NSW, Australia.
1999-2004:
Bachelor of Science (Hons Class I/Bachelor of Law). Macquarie University, NSW, Australia.
Research
Teaching
Contact
Research interests
How does cancer escape from the immune system?
My research is focused on how the immune system distinguishes self from non-self, uncovering the molecular mechanisms that control the recognition of cancer cells, pathogens and non-self cells. This work has applications to understanding how a pathogen interacts with its host and why some cancers are more aggressive and malignant than others.
My laboratory uses non-self and contagious cancers to understand the barrier between self and non-self, immune recognition and pathogen evolution. Cancer is not usually an infectious disease, but in some cases tumour cells acquire the ability to pass between individuals in a population. These cancers can be deadly to the species they infect and also challenge our understanding of how tumours grow and evolve. We focus on two examples in the Tasmanian devil, Devil Facial Tumour Disease 1 and 2, in addition to other cancer models, including choriocarcinoma, a cancer of the foetus that can invade maternal tissues.
The proteins responsible for recognising pathogens and cancer cells are called Major Histocompatibility Complex (MHC) molecules, which are variable between individuals in a population. These molecules are essential for communicating to the immune system that a cell is self, non-self, infected or malignant. Our research is focused on why and how the MHC system 'breaks down' and fails to recognise these cancers.
Media articles on contagious cancers, immune evasion and vaccine strategies:
Solent TV on YouTube describing new efforts at a vaccine against DFTD.
An interactive multimedia from the
site of the Wellcome Genome Campus, which tells the story of Devil Facial Tumour Disease and outlines what we are doing to save the species. It is aimed at primary school children.
An interview with the Naked Scientists.
A nature news article explaining the new strategies for a vaccine against DFTD.
MPhil/PhD research:
Investigation of the molecular mechanisms behind immune escape and recognition of a contagious cancer.
Supervisors: Dr Hannah Siddle and Professor Tim Elliott
Funded by the Gerald Kerkut Charitable Trust
Identifying peptide candidates for a vaccine against the contagious cancer, Devil Facial Tumour Disease
Cancer is not usually an infectious disease, but in some cases tumour cells acquire the ability to pass between individuals in a population. We are particularly interested in the two contagious cancers that circulate in the Tasmanian devil population, DFT1 and DFT2. Our research is focused on why and how the MHC system ‘breaks down’ in the case of contagious cancers.
Programme Lead for Biochemistry
Module Coordinator
Biol1025
Fundamentals of Cell Biology and Physiology
Lecturer
Biol1025
Fundamentals of Cell Biology and Physiology
Biol1027
The Human Genome and Disease
BIOL2022
Immunology, Infection and Inflammation
BIOL3064
Cancer Chromosome Biology
BIOL3022
Cell Signaling in Health and Disease
Dr Hannah V Siddle
School of Biological Sciences
Faculty of Environmental and Life Sciences
Life Sciences Building 85
ºÚÁÏÉç
Highfield Campus
Southampton
SO17 1BJ
